Principal Hardware Engineer - Fluidics - Pleasanton, CA

Are you ready to change the future of kidney stone treatment? We are seeking high achievers who want to be part of a dynamic team working in a fun, diverse atmosphere.

We are seeking a highly skilled and innovative hardware engineer to lead development of advanced fluidic subsystems in kidney stone treatment. This role focuses on the design and control of irrigation and aspiration systems, combining pumps, valves, sensors, tubing sets, and embedded software into safe and reliable ...

Own and architect end-to-end fluid control systems across capital equipment and disposable instruments/tubing sets.

Bachelor’s degree in Mechanical Engineering, Biomedical Engineering, Electrical Engineering, Mechatronics, or a related discipline. Master’s or PhD in a relevant engineering discipline preferred. 
15+ years of experience developing fluidic, mechatronic, or control systems in a regulated product environment. 
Experience with owning end-to-end hardware system architectures for fluidic control systems. Preferred familiarity with disposable fluidic component design and reusable/disposable system interfaces. 
Proven experience developing and tuning closed‑loop control systems for electromechanical hardware. Preferred experience with irrigation and aspiration systems, endoscopic or urological devices, or surgical fluid management platforms. Experience with pressure, flow, air‑in‑line, or occlusion detection preferred. 
Experience prototyping and testing systems at the bench and subsystem level, including proficiency with prototype embedded software development (e.g., C/C++, Python, or similar) to support hardware designs. 
Strong first-principles thinker with expert-level fundamentals in fluid dynamics applied to precision fluid delivery in complex devices. 
Ability to design experiments, analyze data, and translate results into design improvements. 
Clear technical communication skills and ability to influence across multidisciplinary teams. 
Experience leading external vendors and contract development firms.  
Exceptional structured problem-solving skills and experience leading multifunctional technical project teams through all development lifecycle phases.  
Prior work on medical devices or other safety‑critical products, including knowledge of IEC 60601, ISO 13485, and medical device design controls. 
Experience in requirements definition, design reviews, design verification, change management and risk control  
Ability to travel domestically and internationally up to 10% of the time. 

 
 
 
 
At Calyxo, you will be part of a knowledgeable, high-achieving, experienced, and fun team.  You will work in a diverse work environment with experienced, proven leaders and have an opportunity to shape our company culture.  You will experience constant learning and dynamic challenges to help you grow and be the best version of yourself.   
 
We also offer an attractive compensation package, which includes: 
A competitive base salary of $250,000 - $270,000 and variable incentive plan  
Stock options – ownership and a stake in growing a mission-driven company 
Employee benefits package that includes 401(k), healthcare insurance and paid vacation 
Calyxo is deeply committed to fostering an environment where diversity and inclusion are not only valued but also prioritized. We believe a diverse and inclusive community empowers us to act courageously, care deeply, and dream boldly to impact people in big ways. Diverse viewpoints bring diverse capabilities, which strengthen our focus and fuel our growth. 
 
Calyxo is proud to be an